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Mitochondrial GTP Regulates Glucose-Induced Insulin Secretion

Substrate-level mitochondrial GTP (mtGTP) and ATP (mtATP) synthesis occurs by nucleotide-specific isoforms of the tricarboxylic acid (TCA) cycle enzyme succinyl CoA synthetase (SCS). Unlike mtATP, each molecule of glucose metabolized produces approximately one mtGTP in pancreatic β-cells independent...

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Main Authors: Kibbey, Richard G., Pongratz, Rebecca L., Romanelli, Anthony J., Wollheim, Claes B., Cline, Gary W., Shulman, Gerald I.
格式: Artigo
語言:Inglês
出版: 2007
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1876711/
https://ncbi.nlm.nih.gov/pubmed/17403370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2007.02.008
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