Mitochondrial Dysfunction Contributes to Impaired Insulin Secretion in INS-1 Cells with Dominant-negative Mutations of HNF-1α and in HNF-1α-deficient Islets

Maturity Onset Diabetes of the Young-type 3 (MODY-3) has been linked to mutations in the transcription factor hepatic nuclear factor (HNF)-1α, resulting in deficiency in glucose-stimulated insulin secretion. In INS-1 cells overexpressing doxycycline-inducible HNF-1α dominant-negative (DN-) gene muta...

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Autors principals: Pongratz, Rebecca L., Kibbey, Richard G., Kirkpatrick, Clare L., Zhao, Xiaojian, Pontoglio, Marco, Yaniv, Moshe, Wollheim, Claes B., Shulman, Gerald I., Cline, Gary W.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2009
Matèries:
Metabolism and Bioenergetics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719317/
https://ncbi.nlm.nih.gov/pubmed/19376774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807723200
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