Hepatic Nuclear Factor 1α (HNF1α) Dysfunction Down-regulates X-box-binding Protein 1 (XBP1) and Sensitizes β-Cells to Endoplasmic Reticulum Stress

Correct endoplasmic reticulum (ER) function is critical for the health of secretory cells, such as the pancreatic β-cell, and ER stress is often a contributory factor to β-cell death in type 2 diabetes. We have used an insulin-secreting cell line with inducible expression of dominant negative (DN) H...

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Detalhes bibliográficos
Main Authors: Kirkpatrick, Clare L., Wiederkehr, Andreas, Baquié, Mathurin, Akhmedov, Dmitry, Wang, Haiyan, Gauthier, Benoit R., Akerman, Ildem, Ishihara, Hisamitsu, Ferrer, Jorge, Wollheim, Claes B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173152/
https://ncbi.nlm.nih.gov/pubmed/21784843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.247866
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