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Molecular targets of a human HNF1α mutation responsible for pancreatic β-cell dysfunction
The reverse tetracycline-dependent transactivator system was employed in insulinoma INS-1 cells to achieve controlled inducible expression of hepatocyte nuclear factor-1α (HNF1α)-P291fsinsC, the most common mutation associated with subtype 3 of maturity-onset diabetes of the young (MODY3). Nuclear l...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC302029/ https://ncbi.nlm.nih.gov/pubmed/10944108 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.16.4257 |
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