Profound defects in pancreatic β-cell function in mice with combined heterozygous mutations in Pdx-1, Hnf-1α, and Hnf-3β

Defects in pancreatic β-cell function contribute to the development of type 2 diabetes, a polygenic disease that is characterized by insulin resistance and compromised insulin secretion. Hepatocyte nuclear factors (HNFs) -1α, -3β, -4α, and Pdx-1 contribute in the complex transcriptional circuits wit...

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Bibliografiska uppgifter
Huvudupphovsmän: Shih, David Q., Heimesaat, Markus, Kuwajima, Satoru, Stein, Roland, Wright, Christopher V. E., Stoffel, Markus
Materialtyp: Artigo
Språk:Inglês
Publicerad: The National Academy of Sciences 2002
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC122607/
https://ncbi.nlm.nih.gov/pubmed/11904435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.062605899
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