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Impact of Pdx1-associated chromatin modifiers on islet β-cells

Diabetes mellitus arises from insufficient insulin secretion from pancreatic islet β-cells. In type 2 diabetes (T2D), β-cell dysfunction is associated with inactivation and/or loss of transcription factor activity, including Pdx1. Notably, this particular transcription factor is viewed as a master r...

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Bibliografske podrobnosti
izdano v:Diabetes Obes Metab
Main Authors: Spaeth, Jason M., Walker, Emily, Stein, Roland
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5918695/
https://ncbi.nlm.nih.gov/pubmed/27615141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/dom.12730
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