Mafa Enables Pdx1 to Effectively Convert Pancreatic Islet Progenitors and Committed Islet α-Cells Into β-Cells In Vivo

Among the therapeutic avenues being explored for replacement of the functional islet β-cell mass lost in type 1 diabetes (T1D), reprogramming of adult cell types into new β-cells has been actively pursued. Notably, mouse islet α-cells will transdifferentiate into β-cells under conditions of near β-c...

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Detalles Bibliográficos
Publicado en:Diabetes
Autores principales: Matsuoka, Taka-aki, Kawashima, Satoshi, Miyatsuka, Takeshi, Sasaki, Shugo, Shimo, Naoki, Katakami, Naoto, Kawamori, Dan, Takebe, Satomi, Herrera, Pedro L., Kaneto, Hideaki, Stein, Roland, Shimomura, Iichiro
Formato: Artigo
Lenguaje:Inglês
Publicado: American Diabetes Association 2017
Materias:
Islet Studies
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5399608/
https://ncbi.nlm.nih.gov/pubmed/28223284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db16-0887
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