Regulation of MafA Expression in Pancreatic β-Cells in db/db Mice With Diabetes

OBJECTIVE: Islet β-cells loose their ability to synthesize insulin under diabetic conditions, which is at least partially due to the decreased activity of insulin transcription factors such as MafA. Although an in vitro study showed that reactive oxygen species (ROS) decrease MafA expression, the un...

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Detalhes bibliográficos
Main Authors: Matsuoka, Taka-aki, Kaneto, Hideaki, Miyatsuka, Takeshi, Yamamoto, Tsunehiko, Yamamoto, Kaoru, Kato, Ken, Shimomura, Iichiro, Stein, Roland, Matsuhisa, Munehide
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2010
Assuntos:
Islet Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889771/
https://ncbi.nlm.nih.gov/pubmed/20424231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-0693
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