Regulation of MafA Expression in Pancreatic β-Cells in db/db Mice With Diabetes

OBJECTIVE: Islet β-cells loose their ability to synthesize insulin under diabetic conditions, which is at least partially due to the decreased activity of insulin transcription factors such as MafA. Although an in vitro study showed that reactive oxygen species (ROS) decrease MafA expression, the un...

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Auteurs principaux: Matsuoka, Taka-aki, Kaneto, Hideaki, Miyatsuka, Takeshi, Yamamoto, Tsunehiko, Yamamoto, Kaoru, Kato, Ken, Shimomura, Iichiro, Stein, Roland, Matsuhisa, Munehide
Format: Artigo
Langue:Inglês
Publié: American Diabetes Association 2010
Sujets:
Islet Studies
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889771/
https://ncbi.nlm.nih.gov/pubmed/20424231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-0693
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