Regulation of MafA Expression in Pancreatic β-Cells in db/db Mice With Diabetes

OBJECTIVE: Islet β-cells loose their ability to synthesize insulin under diabetic conditions, which is at least partially due to the decreased activity of insulin transcription factors such as MafA. Although an in vitro study showed that reactive oxygen species (ROS) decrease MafA expression, the un...

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Autori principali: Matsuoka, Taka-aki, Kaneto, Hideaki, Miyatsuka, Takeshi, Yamamoto, Tsunehiko, Yamamoto, Kaoru, Kato, Ken, Shimomura, Iichiro, Stein, Roland, Matsuhisa, Munehide
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Diabetes Association 2010
Soggetti:
Islet Studies
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889771/
https://ncbi.nlm.nih.gov/pubmed/20424231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-0693
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