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Role for malic enzyme, pyruvate carboxylation, and mitochondrial malate import in glucose-stimulated insulin secretion

Pyruvate cycling has been implicated in glucose-stimulated insulin secretion (GSIS) from pancreatic β-cells. The operation of some pyruvate cycling pathways is proposed to necessitate malate export from the mitochondria and NADP(+)-dependent decarboxylation of malate to pyruvate by cytosolic malic e...

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Bibliografski detalji
Glavni autori: Heart, Emma, Cline, Gary W., Collis, Leon P., Pongratz, Rebecca L., Gray, Joshua P., Smith, Peter J. S.
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2692397/
https://ncbi.nlm.nih.gov/pubmed/19293334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.90836.2008
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