β-Cell-specific pyruvate dehydrogenase deficiency impairs glucose-stimulated insulin secretion

Glucose-stimulated insulin secretion (GSIS) by β-cells requires the generation of ATP from oxidation of pyruvate as well as generation of coupling factors involving three different pyruvate cycling shuttles. The roles of several key enzymes involved in pyruvate cycling in β-cells have been documente...

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Main Authors: Srinivasan, Malathi, Choi, Cheol S., Ghoshal, Pushpankur, Pliss, Lioudmila, Pandya, Jignesh D., Hill, David, Cline, Gary, Patel, Mulchand S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3006256/
https://ncbi.nlm.nih.gov/pubmed/20841503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00339.2010
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