Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA)

Hepatic mitochondria play a central role in the regulation of intermediary metabolism and maintenance of normoglycemia, and there is great interest in assessing rates of hepatic mitochondrial citrate synthase flux (V(CS)) and pyruvate carboxylase flux (V(PC)) in vivo. Here, we show that a positional...

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Publicat a:Nat Commun
Autors principals: Perry, Rachel J., Peng, Liang, Cline, Gary W., Butrico, Gina M., Wang, Yongliang, Zhang, Xian-Man, Rothman, Douglas L., Petersen, Kitt Falk, Shulman, Gerald I.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5630596/
https://ncbi.nlm.nih.gov/pubmed/28986525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01143-w
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