Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA)

Hepatic mitochondria play a central role in the regulation of intermediary metabolism and maintenance of normoglycemia, and there is great interest in assessing rates of hepatic mitochondrial citrate synthase flux (V(CS)) and pyruvate carboxylase flux (V(PC)) in vivo. Here, we show that a positional...

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izdano v:Nat Commun
Main Authors: Perry, Rachel J., Peng, Liang, Cline, Gary W., Butrico, Gina M., Wang, Yongliang, Zhang, Xian-Man, Rothman, Douglas L., Petersen, Kitt Falk, Shulman, Gerald I.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2017
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5630596/
https://ncbi.nlm.nih.gov/pubmed/28986525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01143-w
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