Pathogenic Mutations in the Valosin-containing Protein/p97(VCP) N-domain Inhibit the SUMOylation of VCP and Lead to Impaired Stress Response

Valosin-containing protein/p97(VCP) is a hexameric ATPase vital to protein degradation during endoplasmic reticulum stress. It regulates diverse cellular functions including autophagy, chromatin remodeling, and DNA repair. In addition, mutations in VCP cause inclusion body myopathy, Paget disease of...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Wang, Tao, Xu, Wangchao, Qin, Meiling, Yang, Yi, Bao, Puhua, Shen, Fuxiao, Zhang, Zhenlin, Xu, Jin
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2016
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933190/
https://ncbi.nlm.nih.gov/pubmed/27226613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.729343
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