COP9 Signalosome Interacts ATP-dependently with p97/Valosin-containing Protein (VCP) and Controls the Ubiquitination Status of Proteins Bound to p97/VCP

Ubiquitinated proteins can alternatively be delivered directly to the proteasome or via p97/VCP (valosin-containing protein). Whereas the proteasome degrades ubiquitinated proteins, the homohexameric ATPase p97/VCP seems to control the ubiquitination status of recruited substrates. The COP9 signalos...

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Bibliographic Details
Main Authors: Cayli, Sevil, Klug, Jörg, Chapiro, Julius, Fröhlich, Suada, Krasteva, Gabriela, Orel, Lukas, Meinhardt, Andreas
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Protein Synthesis, Post-Translational Modification, and Degradation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787357/
https://ncbi.nlm.nih.gov/pubmed/19826004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.037952
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