Valosin-Containing Protein (VCP/p97) Is an Activator of Wild-Type Ataxin-3

Alterations in the ubiquitin-proteasome system (UPS) have been reported in several neurodegenerative disorders characterized by protein misfolding and aggregation, including the polylgutamine diseases. Machado-Joseph disease (MJD) or Spinocerebellar Ataxia type 3 is caused by a polyglutamine-encodin...

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Autori principali: Laço, Mário N., Cortes, Luisa, Travis, Sue M., Paulson, Henry L., Rego, A. Cristina
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3435318/
https://ncbi.nlm.nih.gov/pubmed/22970133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043563
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