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Valosin-Containing Protein (VCP/p97) is Capable of Unfolding Polyubiquitinated Proteins through Its ATPase Domains
Valosin-containing protein (VCP or p97) is required for the proteasomal degradation of polyubiquitinated proteins. However, the molecular mechanism for VCP to process the polyubiquitinated proteins remains unclear. Here, we show that VCP can unfold polyubiquitinated proteins. It preferably unfolds t...
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Publicado no: | Biochem Biophys Res Commun |
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Main Authors: | , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2015
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4470855/ https://ncbi.nlm.nih.gov/pubmed/26043696 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2015.05.111 |
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