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Valosin-Containing Protein (VCP/p97) is Capable of Unfolding Polyubiquitinated Proteins through Its ATPase Domains

Valosin-containing protein (VCP or p97) is required for the proteasomal degradation of polyubiquitinated proteins. However, the molecular mechanism for VCP to process the polyubiquitinated proteins remains unclear. Here, we show that VCP can unfold polyubiquitinated proteins. It preferably unfolds t...

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Detalhes bibliográficos
Publicado no:Biochem Biophys Res Commun
Main Authors: Song, Changcheng, Wang, Qing, Song, Changzheng, Rogers, Thomas J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4470855/
https://ncbi.nlm.nih.gov/pubmed/26043696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2015.05.111
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