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Valosin-Containing Protein (VCP/p97) is Capable of Unfolding Polyubiquitinated Proteins through Its ATPase Domains
Valosin-containing protein (VCP or p97) is required for the proteasomal degradation of polyubiquitinated proteins. However, the molecular mechanism for VCP to process the polyubiquitinated proteins remains unclear. Here, we show that VCP can unfold polyubiquitinated proteins. It preferably unfolds t...
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| 出版年: | Biochem Biophys Res Commun |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4470855/ https://ncbi.nlm.nih.gov/pubmed/26043696 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2015.05.111 |
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