Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels

Metabolic reprogramming is emerging as a hallmark of the innate immune response, and the dynamic control of metabolites such as succinate serves to facilitate the execution of inflammatory responses in macrophages and other immune cells. Immunoresponsive gene 1 (Irg1) expression is induced by inflam...

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Foilsithe in:J Biol Chem
Main Authors: Cordes, Thekla, Wallace, Martina, Michelucci, Alessandro, Divakaruni, Ajit S., Sapcariu, Sean C., Sousa, Carole, Koseki, Haruhiko, Cabrales, Pedro, Murphy, Anne N., Hiller, Karsten, Metallo, Christian M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2016
Ábhair:
Metabolism
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933182/
https://ncbi.nlm.nih.gov/pubmed/27189937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.685792
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