Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels

Metabolic reprogramming is emerging as a hallmark of the innate immune response, and the dynamic control of metabolites such as succinate serves to facilitate the execution of inflammatory responses in macrophages and other immune cells. Immunoresponsive gene 1 (Irg1) expression is induced by inflam...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Cordes, Thekla, Wallace, Martina, Michelucci, Alessandro, Divakaruni, Ajit S., Sapcariu, Sean C., Sousa, Carole, Koseki, Haruhiko, Cabrales, Pedro, Murphy, Anne N., Hiller, Karsten, Metallo, Christian M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933182/
https://ncbi.nlm.nih.gov/pubmed/27189937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.685792
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