Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production

Immunoresponsive gene 1 (Irg1) is highly expressed in mammalian macrophages during inflammation, but its biological function has not yet been elucidated. Here, we identify Irg1 as the gene coding for an enzyme producing itaconic acid (also known as methylenesuccinic acid) through the decarboxylation...

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Bibliografiske detaljer
Main Authors: Michelucci, Alessandro, Cordes, Thekla, Ghelfi, Jenny, Pailot, Arnaud, Reiling, Norbert, Goldmann, Oliver, Binz, Tina, Wegner, André, Tallam, Aravind, Rausell, Antonio, Buttini, Manuel, Linster, Carole L., Medina, Eva, Balling, Rudi, Hiller, Karsten
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2013
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3651434/
https://ncbi.nlm.nih.gov/pubmed/23610393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1218599110
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