Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production

Immunoresponsive gene 1 (Irg1) is highly expressed in mammalian macrophages during inflammation, but its biological function has not yet been elucidated. Here, we identify Irg1 as the gene coding for an enzyme producing itaconic acid (also known as methylenesuccinic acid) through the decarboxylation...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Michelucci, Alessandro, Cordes, Thekla, Ghelfi, Jenny, Pailot, Arnaud, Reiling, Norbert, Goldmann, Oliver, Binz, Tina, Wegner, André, Tallam, Aravind, Rausell, Antonio, Buttini, Manuel, Linster, Carole L., Medina, Eva, Balling, Rudi, Hiller, Karsten
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: National Academy of Sciences 2013
विषय:
Biological Sciences
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3651434/
https://ncbi.nlm.nih.gov/pubmed/23610393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1218599110
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