Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production

Immunoresponsive gene 1 (Irg1) is highly expressed in mammalian macrophages during inflammation, but its biological function has not yet been elucidated. Here, we identify Irg1 as the gene coding for an enzyme producing itaconic acid (also known as methylenesuccinic acid) through the decarboxylation...

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Główni autorzy: Michelucci, Alessandro, Cordes, Thekla, Ghelfi, Jenny, Pailot, Arnaud, Reiling, Norbert, Goldmann, Oliver, Binz, Tina, Wegner, André, Tallam, Aravind, Rausell, Antonio, Buttini, Manuel, Linster, Carole L., Medina, Eva, Balling, Rudi, Hiller, Karsten
Format: Artigo
Język:Inglês
Wydane: National Academy of Sciences 2013
Hasła przedmiotowe:
Biological Sciences
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3651434/
https://ncbi.nlm.nih.gov/pubmed/23610393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1218599110
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