Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production

Immunoresponsive gene 1 (Irg1) is highly expressed in mammalian macrophages during inflammation, but its biological function has not yet been elucidated. Here, we identify Irg1 as the gene coding for an enzyme producing itaconic acid (also known as methylenesuccinic acid) through the decarboxylation...

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Detalhes bibliográficos
Main Authors: Michelucci, Alessandro, Cordes, Thekla, Ghelfi, Jenny, Pailot, Arnaud, Reiling, Norbert, Goldmann, Oliver, Binz, Tina, Wegner, André, Tallam, Aravind, Rausell, Antonio, Buttini, Manuel, Linster, Carole L., Medina, Eva, Balling, Rudi, Hiller, Karsten
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3651434/
https://ncbi.nlm.nih.gov/pubmed/23610393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1218599110
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