Pro-inflammatory Macrophages Sustain Pyruvate Oxidation through Pyruvate Dehydrogenase for the Synthesis of Itaconate and to Enable Cytokine Expression

Upon stimulation with Th1 cytokines or bacterial lipopolysaccharides, resting macrophages shift their phenotype toward a pro-inflammatory state as part of the innate immune response. LPS-activated macrophages undergo profound metabolic changes to adapt to these new physiological requirements. One ke...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Meiser, Johannes, Krämer, Lisa, Sapcariu, Sean C., Battello, Nadia, Ghelfi, Jenny, D'Herouel, Aymeric Fouquier, Skupin, Alexander, Hiller, Karsten
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2016
Matèries:
Metabolism
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4759172/
https://ncbi.nlm.nih.gov/pubmed/26679997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.676817
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