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Pro-inflammatory Macrophages Sustain Pyruvate Oxidation through Pyruvate Dehydrogenase for the Synthesis of Itaconate and to Enable Cytokine Expression

Upon stimulation with Th1 cytokines or bacterial lipopolysaccharides, resting macrophages shift their phenotype toward a pro-inflammatory state as part of the innate immune response. LPS-activated macrophages undergo profound metabolic changes to adapt to these new physiological requirements. One ke...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Meiser, Johannes, Krämer, Lisa, Sapcariu, Sean C., Battello, Nadia, Ghelfi, Jenny, D'Herouel, Aymeric Fouquier, Skupin, Alexander, Hiller, Karsten
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4759172/
https://ncbi.nlm.nih.gov/pubmed/26679997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.676817
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