Pro-inflammatory Macrophages Sustain Pyruvate Oxidation through Pyruvate Dehydrogenase for the Synthesis of Itaconate and to Enable Cytokine Expression

Upon stimulation with Th1 cytokines or bacterial lipopolysaccharides, resting macrophages shift their phenotype toward a pro-inflammatory state as part of the innate immune response. LPS-activated macrophages undergo profound metabolic changes to adapt to these new physiological requirements. One ke...

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書目詳細資料
發表在:J Biol Chem
Main Authors: Meiser, Johannes, Krämer, Lisa, Sapcariu, Sean C., Battello, Nadia, Ghelfi, Jenny, D'Herouel, Aymeric Fouquier, Skupin, Alexander, Hiller, Karsten
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2016
主題:
Metabolism
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4759172/
https://ncbi.nlm.nih.gov/pubmed/26679997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.676817
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