Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels

Metabolic reprogramming is emerging as a hallmark of the innate immune response, and the dynamic control of metabolites such as succinate serves to facilitate the execution of inflammatory responses in macrophages and other immune cells. Immunoresponsive gene 1 (Irg1) expression is induced by inflam...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:J Biol Chem
Main Authors: Cordes, Thekla, Wallace, Martina, Michelucci, Alessandro, Divakaruni, Ajit S., Sapcariu, Sean C., Sousa, Carole, Koseki, Haruhiko, Cabrales, Pedro, Murphy, Anne N., Hiller, Karsten, Metallo, Christian M.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2016
נושאים:
Metabolism
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933182/
https://ncbi.nlm.nih.gov/pubmed/27189937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.685792
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