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Rational design and validation of a vanilloid-sensitive TRPV2 ion channel
Vanilloids activation of TRPV1 represents an excellent model system of ligand-gated ion channels. Recent studies using cryo-electron microcopy (cryo-EM), computational analysis, and functional quantification revealed the location of capsaicin-binding site and critical residues mediating ligand-bindi...
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| Izdano u: | Proc Natl Acad Sci U S A |
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| Glavni autori: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2016
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4932969/ https://ncbi.nlm.nih.gov/pubmed/27298359 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1604180113 |
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