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Structural mechanism underlying capsaicin binding and activation of TRPV1 ion channel
Capsaicin bestows spiciness by activating TRPV1 channel with exquisite potency and selectivity. Capsaicin-bound channel structure was previously resolved by cryo-EM at 4.2-to-4.5 Å resolution, however important details required for mechanistic understandings are unavailable: capsaicin was registered...
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| Pubblicato in: | Nat Chem Biol |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4472570/ https://ncbi.nlm.nih.gov/pubmed/26053297 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1835 |
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