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Selective disruption of high sensitivity heat activation but not capsaicin activation of TRPV1 channels by pore turret mutations
The capsaicin receptor transient receptor potential vanilloid (TRPV)1 is a highly heat-sensitive ion channel. Although chemical activation and heat activation of TRPV1 elicit similar pungent, painful sensation, the molecular mechanism underlying synergistic activation remains mysterious. In particul...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3315147/ https://ncbi.nlm.nih.gov/pubmed/22412190 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201110724 |
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