Učitavanje...
TRPV1 pore turret dictates distinct DkTx and capsaicin gating
Many neurotoxins inflict pain by targeting receptors expressed on nociceptors, such as the polymodal cationic channel TRPV1. The tarantula double-knot toxin (DkTx) is a peptide with an atypical bivalent structure, providing it with the unique capability to lock TRPV1 in its open state and evoke an i...
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| Izdano u: | Proc Natl Acad Sci U S A |
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| Glavni autori: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2018
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6294906/ https://ncbi.nlm.nih.gov/pubmed/30463948 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1809662115 |
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