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TRPV1 pore turret dictates distinct DkTx and capsaicin gating

Many neurotoxins inflict pain by targeting receptors expressed on nociceptors, such as the polymodal cationic channel TRPV1. The tarantula double-knot toxin (DkTx) is a peptide with an atypical bivalent structure, providing it with the unique capability to lock TRPV1 in its open state and evoke an i...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Geron, Matan, Kumar, Rakesh, Zhou, Wenchang, Faraldo-Gómez, José D., Vásquez, Valeria, Priel, Avi
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2018
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6294906/
https://ncbi.nlm.nih.gov/pubmed/30463948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1809662115
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