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The conformational wave in capsaicin activation of transient receptor potential vanilloid 1 ion channel

The capsaicin receptor TRPV1 has been intensively studied by cryo-electron microscopy and functional tests. However, though the apo and capsaicin-bound structural models are available, the dynamic process of capsaicin activation remains intangible, largely due to the lack of a capsaicin-induced open...

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Vydáno v:Nat Commun
Hlavní autoři: Yang, Fan, Xiao, Xian, Lee, Bo Hyun, Vu, Simon, Yang, Wei, Yarov-Yarovoy, Vladimir, Zheng, Jie
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6056546/
https://ncbi.nlm.nih.gov/pubmed/30038260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05339-6
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