CD80 down-regulation is associated to aberrant DNA methylation in non-inflammatory colon carcinogenesis

BACKGROUND: The lack of positive costimulatory molecules represents one of the mechanisms by which tumor cells evade immune surveillance. Promoter hypermethylation plays a major role in cancer development through transcriptional silencing of critical genes. The aim of this study was to examine the e...

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Bibliographic Details
Published in:BMC Cancer
Main Authors: Scarpa, Marco, Scarpa, Melania, Castagliuolo, Ignazio, Erroi, Francesca, Basato, Silvia, Brun, Paola, Angriman, Imerio, Castoro, Carlo
Format: Artigo
Language:Inglês
Published: BioMed Central 2016
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4932699/
https://ncbi.nlm.nih.gov/pubmed/27377375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2405-z
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