Epithelial CD80 promotes immune surveillance of colonic preneoplastic lesions and its expression is increased by oxidative stress through STAT3 in colon cancer cells

BACKGROUND: One of the most potent costimulatory molecules involved in the recognition and killing of tumor cells is CD80. However, its role and the molecular mechanisms regulating its expression in sporadic colorectal carcinogenesis remain elusive. Here, we provide evidence for CD80 overexpression...

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Bibliografiske detaljer
Udgivet i:J Exp Clin Cancer Res
Main Authors: Marchiori, Chiara, Scarpa, Melania, Kotsafti, Andromachi, Morgan, Susan, Fassan, Matteo, Guzzardo, Vincenza, Porzionato, Andrea, Angriman, Imerio, Ruffolo, Cesare, Sut, Stefania, Dall’Acqua, Stefano, Bardini, Romeo, De Caro, Raffaele, Castoro, Carlo, Scarpa, Marco, Castagliuolo, Ignazio
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6509793/
https://ncbi.nlm.nih.gov/pubmed/31072360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1205-0
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