RAB2A controls MT1‐MMP endocytic and E‐cadherin polarized Golgi trafficking to promote invasive breast cancer programs

The mechanisms of tumor cell dissemination and the contribution of membrane trafficking in this process are poorly understood. Through a functional siRNA screening of human RAB GTPases, we found that RAB2A, a protein essential for ER‐to‐Golgi transport, is critical in promoting proteolytic activity...

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Detalhes bibliográficos
Publicado no:EMBO Rep
Main Authors: Kajiho, Hiroaki, Kajiho, Yuko, Frittoli, Emanuela, Confalonieri, Stefano, Bertalot, Giovanni, Viale, Giuseppe, Di Fiore, Pier Paolo, Oldani, Amanda, Garre, Massimiliano, Beznoussenko, Galina V, Palamidessi, Andrea, Vecchi, Manuela, Chavrier, Philippe, Perez, Frank, Scita, Giorgio
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4931572/
https://ncbi.nlm.nih.gov/pubmed/27255086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201642032
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