A RAB5/RAB4 recycling circuitry induces a proteolytic invasive program and promotes tumor dissemination

The mechanisms by which tumor cells metastasize and the role of endocytic proteins in this process are not well understood. We report that overexpression of the GTPase RAB5A, a master regulator of endocytosis, is predictive of aggressive behavior and metastatic ability in human breast cancers. RAB5A...

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Bibliografski detalji
Glavni autori: Frittoli, Emanuela, Palamidessi, Andrea, Marighetti, Paola, Confalonieri, Stefano, Bianchi, Fabrizio, Malinverno, Chiara, Mazzarol, Giovanni, Viale, Giuseppe, Martin-Padura, Ines, Garré, Massimilliano, Parazzoli, Dario, Mattei, Valentina, Cortellino, Salvatore, Bertalot, Giovanni, Di Fiore, Pier Paolo, Scita, Giorgio
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2014
Teme:
Research Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4107781/
https://ncbi.nlm.nih.gov/pubmed/25049275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201403127
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