RAB2A controls MT1‐MMP endocytic and E‐cadherin polarized Golgi trafficking to promote invasive breast cancer programs

The mechanisms of tumor cell dissemination and the contribution of membrane trafficking in this process are poorly understood. Through a functional siRNA screening of human RAB GTPases, we found that RAB2A, a protein essential for ER‐to‐Golgi transport, is critical in promoting proteolytic activity...

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Vydáno v:EMBO Rep
Hlavní autoři: Kajiho, Hiroaki, Kajiho, Yuko, Frittoli, Emanuela, Confalonieri, Stefano, Bertalot, Giovanni, Viale, Giuseppe, Di Fiore, Pier Paolo, Oldani, Amanda, Garre, Massimiliano, Beznoussenko, Galina V, Palamidessi, Andrea, Vecchi, Manuela, Chavrier, Philippe, Perez, Frank, Scita, Giorgio
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2016
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Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4931572/
https://ncbi.nlm.nih.gov/pubmed/27255086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201642032
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