Menadione-Induced DNA Damage Leads to Mitochondrial Dysfunction and Fragmentation During Rosette Formation in Fuchs Endothelial Corneal Dystrophy

Aims: Fuchs endothelial corneal dystrophy (FECD), a leading cause of age-related corneal edema requiring transplantation, is characterized by rosette formation of corneal endothelium with ensuing apoptosis. We sought to determine whether excess of mitochondrial reactive oxygen species leads to chron...

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Pubblicato in:Antioxid Redox Signal
Autori principali: Halilovic, Adna, Schmedt, Thore, Benischke, Anne-Sophie, Hamill, Cecily, Chen, Yuming, Santos, Janine Hertzog, Jurkunas, Ula V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Mary Ann Liebert, Inc. 2016
Soggetti:
Original Research Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4931310/
https://ncbi.nlm.nih.gov/pubmed/26935406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2015.6532
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