Mitochondria-targeted analogs of metformin exhibit enhanced antiproliferative and radiosensitizing effects in pancreatic cancer cells

Metformin (Met) is an approved antidiabetic drug currently being explored for repurposing in cancer treatment based on recent evidence of its apparent chemopreventive properties. Met is weakly cationic and targets the mitochondria to induce cytotoxic effects in tumor cells, albeit not very effective...

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Bibliografski detalji
Izdano u:Cancer Res
Glavni autori: Cheng, Gang, Zielonka, Jacek, Ouari, Olivier, Lopez, Marcos, McAllister, Donna, Boyle, Kathleen, Barrios, Christy S., Weber, James J., Johnson, Bryon D., Hardy, Micael, Dwinell, Michael B., Kalyanaraman, Balaraman
Format: Artigo
Jezik:Inglês
Izdano: 2016
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4930686/
https://ncbi.nlm.nih.gov/pubmed/27216187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-2534
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