Mitochondria-targeted analogs of metformin exhibit enhanced antiproliferative and radiosensitizing effects in pancreatic cancer cells

Metformin (Met) is an approved antidiabetic drug currently being explored for repurposing in cancer treatment based on recent evidence of its apparent chemopreventive properties. Met is weakly cationic and targets the mitochondria to induce cytotoxic effects in tumor cells, albeit not very effective...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Cheng, Gang, Zielonka, Jacek, Ouari, Olivier, Lopez, Marcos, McAllister, Donna, Boyle, Kathleen, Barrios, Christy S., Weber, James J., Johnson, Bryon D., Hardy, Micael, Dwinell, Michael B., Kalyanaraman, Balaraman
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4930686/
https://ncbi.nlm.nih.gov/pubmed/27216187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-2534
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