11β-Hydroxysteroid Dehydrogenase Type 1 Is Expressed in Neutrophils and Restrains an Inflammatory Response in Male Mice

Endogenous glucocorticoid action within cells is enhanced by prereceptor metabolism by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which converts intrinsically inert cortisone and 11-dehydrocorticosterone into active cortisol and corticosterone, respectively. 11β-HSD1 is highly expressed in...

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Publicat a:Endocrinology
Autors principals: Coutinho, Agnes E., Kipari, Tiina M. J., Zhang, Zhenguang, Esteves, Cristina L., Lucas, Christopher D., Gilmour, James S., Webster, Scott P., Walker, Brian R., Hughes, Jeremy, Savill, John S., Seckl, Jonathan R., Rossi, Adriano G., Chapman, Karen E.
Format: Artigo
Idioma:Inglês
Publicat: Endocrine Society 2016
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4929552/
https://ncbi.nlm.nih.gov/pubmed/27145012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2016-1118
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