11β-Hydroxysteroid Dehydrogenase Type 1 Is Expressed in Neutrophils and Restrains an Inflammatory Response in Male Mice

Endogenous glucocorticoid action within cells is enhanced by prereceptor metabolism by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which converts intrinsically inert cortisone and 11-dehydrocorticosterone into active cortisol and corticosterone, respectively. 11β-HSD1 is highly expressed in...

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Vydáno v:Endocrinology
Hlavní autoři: Coutinho, Agnes E., Kipari, Tiina M. J., Zhang, Zhenguang, Esteves, Cristina L., Lucas, Christopher D., Gilmour, James S., Webster, Scott P., Walker, Brian R., Hughes, Jeremy, Savill, John S., Seckl, Jonathan R., Rossi, Adriano G., Chapman, Karen E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Endocrine Society 2016
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Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4929552/
https://ncbi.nlm.nih.gov/pubmed/27145012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2016-1118
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