11β-Hydroxysteroid Dehydrogenase Type 1 Is Expressed in Neutrophils and Restrains an Inflammatory Response in Male Mice

Endogenous glucocorticoid action within cells is enhanced by prereceptor metabolism by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which converts intrinsically inert cortisone and 11-dehydrocorticosterone into active cortisol and corticosterone, respectively. 11β-HSD1 is highly expressed in...

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Détails bibliographiques
Publié dans:Endocrinology
Auteurs principaux: Coutinho, Agnes E., Kipari, Tiina M. J., Zhang, Zhenguang, Esteves, Cristina L., Lucas, Christopher D., Gilmour, James S., Webster, Scott P., Walker, Brian R., Hughes, Jeremy, Savill, John S., Seckl, Jonathan R., Rossi, Adriano G., Chapman, Karen E.
Format: Artigo
Langue:Inglês
Publié: Endocrine Society 2016
Sujets:
Original Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4929552/
https://ncbi.nlm.nih.gov/pubmed/27145012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2016-1118
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