Mast Cells Express 11β-hydroxysteroid Dehydrogenase Type 1: A Role in Restraining Mast Cell Degranulation

Mast cells are key initiators of allergic, anaphylactic and inflammatory reactions, producing mediators that affect vascular permeability, angiogenesis and fibrosis. Glucocorticoid pharmacotherapy reduces mast cell number, maturation and activation but effects at physiological levels are unknown. Wi...

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Main Authors: Coutinho, Agnes E., Brown, Jeremy K., Yang, Fu, Brownstein, David G., Gray, Mohini, Seckl, Jonathan R., Savill, John S., Chapman, Karen E.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3548897/
https://ncbi.nlm.nih.gov/pubmed/23349944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054640
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