Multi-exon Skipping Using Cocktail Antisense Oligonucleotides in the Canine X-linked Muscular Dystrophy

Duchenne muscular dystrophy (DMD) is one of the most common lethal genetic diseases worldwide, caused by mutations in the dystrophin (DMD) gene. Exon skipping employs short DNA/RNA-like molecules called antisense oligonucleotides (AONs) that restore the reading frame and produce shorter but function...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Vis Exp
Auteurs principaux: Miskew Nichols, Bailey, Aoki, Yoshitsugu, Kuraoka, Mutsuki, Lee, Joshua J.A., Takeda, Shin'ichi, Yokota, Toshifumi
Format: Artigo
Langue:Inglês
Publié: MyJove Corporation 2016
Sujets:
Medicine
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4927712/
https://ncbi.nlm.nih.gov/pubmed/27285612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/53776
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