Sigma-1 Agonist Binding in the Aging Rat Brain: a MicroPET Study with [(11)C]SA4503

PURPOSE: Sigma-1 receptor ligands modulate the release of several neurotransmitters and intracellular calcium signaling. We examined the binding of a radiolabeled sigma-1 agonist in the aging rat brain with positron emission tomography (PET). PROCEDURES: Time-dependent uptake of [(11)C]SA4503 was me...

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Udgivet i:Mol Imaging Biol
Main Authors: Ramakrishnan, Nisha K., Visser, Anniek K. D., Rybczynska, Anna A., Nyakas, Csaba J., Luiten, Paul G. M., Kwizera, Chantal, Sijbesma, Jurgen W. A., Elsinga, Philip H., Ishiwata, Kiichi, Dierckx, Rudi A. J. O., van Waarde, Aren
Format: Artigo
Sprog:Inglês
Udgivet: Springer US 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4927617/
https://ncbi.nlm.nih.gov/pubmed/26637208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11307-015-0917-6
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