Pridopidine selectively occupies sigma-1 rather than dopamine D2 receptors at behaviorally active doses

RATIONALE: Dopamine stabilizers have stimulatory actions under low dopamine tone and inhibitory actions under high dopamine tone without eliciting catalepsy. These compounds are dopamine D(2) receptor (D(2)R) antagonists or weak partial agonists and may have pro-mnemonic and neuroprotective effects....

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Detalhes bibliográficos
Publicado no:Psychopharmacology (Berl)
Main Authors: Sahlholm, Kristoffer, Sijbesma, Jurgen W. A., Maas, Bram, Kwizera, Chantal, Marcellino, Daniel, Ramakrishnan, Nisha K., Dierckx, Rudi A. J. O., Elsinga, Philip H., van Waarde, Aren
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2015
Assuntos:
Original Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4537502/
https://ncbi.nlm.nih.gov/pubmed/26159455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-015-3997-8
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