[(11)C]5-HTP and microPET are not suitable for pharmacodynamic studies in the rodent brain

The PET tracer [(11)C]5-hydroxytryptophan ([(11)C]5-HTP), which is converted to [(11)C]5-hydroxytryptamine ([(11)C]5-HT) by aromatic amino acid decarboxylase (AADC), is thought to measure 5-HT synthesis rates. But can we measure these synthesis rates by kinetic modeling of [(11)C]5-HTP in rat? Male...

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Detalhes bibliográficos
Main Authors: Visser, Anniek KD, Ramakrishnan, Nisha K, Willemsen, Antoon TM, Di Gialleonardo, Valentina, de Vries, Erik FJ, Kema, Ido P, Dierckx, Rudi AJO, van Waarde, Aren
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3887351/
https://ncbi.nlm.nih.gov/pubmed/24084697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2013.171
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