Enhancer of Zeste Homolog 2 Inhibition Attenuates Renal Fibrosis by Maintaining Smad7 and Phosphatase and Tensin Homolog Expression

Enhancer of zeste homolog 2 (EZH2) is a methyltransferase that induces histone H3 lysine 27 trimethylation (H3K27me3) and functions as an oncogenic factor in many cancer types. However, the role of EZH2 in renal fibrogenesis remains unexplored. In this study, we found high expression of EZH2 and H3K...

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Detalles Bibliográficos
Publicado en:J Am Soc Nephrol
Autores principales: Zhou, Xiaoxu, Zang, Xiujuan, Ponnusamy, Murugavel, Masucci, Monica V., Tolbert, Evelyn, Gong, Rujun, Zhao, Ting C., Liu, Na, Bayliss, George, Dworkin, Lance D., Zhuang, Shougang
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Nephrology 2016
Materias:
Basic Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4926973/
https://ncbi.nlm.nih.gov/pubmed/26701983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015040457
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