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Aneuploidy impairs hematopoietic stem cell fitness and is selected against in regenerating tissues in vivo
Aneuploidy, an imbalanced karyotype, is a widely observed feature of cancer cells that has long been hypothesized to promote tumorigenesis. Here we evaluate the fitness of cells with constitutional trisomy or chromosomal instability (CIN) in vivo using hematopoietic reconstitution experiments. We di...
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| Publicado en: | Genes Dev |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Cold Spring Harbor Laboratory Press
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4926863/ https://ncbi.nlm.nih.gov/pubmed/27313317 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.278820.116 |
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