Preclinical Efficacy and Safety Profile of Allometrically Scaled Doses of Doxycycline Used to Turn “On” Therapeutic Transgene Expression from High-Capacity Adenoviral Vectors in a Glioma Model

Glioblastoma multiforme (GBM) is the most commonly occurring primary brain cancer in adults, in whom its highly infiltrative cells prevent total surgical resection, often leading to tumor recurrence and patient death. Our group has discovered a gene therapy approach for GBM that utilizes high-capaci...

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Detalles Bibliográficos
Publicado en:Hum Gene Ther Methods
Main Authors: VanderVeen, Nathan, Raja, Nicholas, Yi, Elizabeth, Appelman, Henry, Ng, Philip, Palmer, Donna, Zamler, Daniel, Dzaman, Marta, Lowenstein, Pedro R., Castro, Maria G.
Formato: Artigo
Idioma:Inglês
Publicado: Mary Ann Liebert, Inc. 2016
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Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4926229/
https://ncbi.nlm.nih.gov/pubmed/27056322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hgtb.2015.168
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