Immunization Against the Transgene but not the TetON Switch Reduces Expression From Gutless Adenoviral Vectors in the Brain

Immune responses against vectors or encoded transgenes can impose limitations on gene therapy. We demonstrated that tetracycline-regulated high-capacity adenoviral vectors (HC-Ads) sustain regulated transgene expression in the brain even in the presence of systemic pre-existing immune responses agai...

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Main Authors: Xiong, Weidong, Candolfi, Marianela, Kroeger, Kurt M, Puntel, Mariana, Mondkar, Sonali, Larocque, Daniel, Liu, Chunyan, Curtin, James F, Palmer, Donna, Ng, Philip, Lowenstein, Pedro R, Castro, Maria G
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2703652/
https://ncbi.nlm.nih.gov/pubmed/18180781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.mt.6300375
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