Cargando...

Immunization Against the Transgene but not the TetON Switch Reduces Expression From Gutless Adenoviral Vectors in the Brain

Immune responses against vectors or encoded transgenes can impose limitations on gene therapy. We demonstrated that tetracycline-regulated high-capacity adenoviral vectors (HC-Ads) sustain regulated transgene expression in the brain even in the presence of systemic pre-existing immune responses agai...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Xiong, Weidong, Candolfi, Marianela, Kroeger, Kurt M, Puntel, Mariana, Mondkar, Sonali, Larocque, Daniel, Liu, Chunyan, Curtin, James F, Palmer, Donna, Ng, Philip, Lowenstein, Pedro R, Castro, Maria G
Formato: Artigo
Idioma:Inglês
Publicado: 2008
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2703652/
https://ncbi.nlm.nih.gov/pubmed/18180781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.mt.6300375
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!