One-year Expression From High-capacity Adenoviral Vectors in the Brains of Animals With Pre-existing Anti-adenoviral Immunity: Clinical Implications

The main challenge of gene therapy is to provide long-term, efficient transgene expression. Long-term transgene expression from first generation adenoviral vectors (Advs) delivered to the central nervous system (CNS) is elicited in animals not previously exposed to adenovirus (Ad). However, upon sys...

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Библиографические подробности
Главные авторы: Barcia, Carlos, Jimenez-Dalmaroni, Maximiliano, Kroeger, Kurt M, Puntel, Mariana, Rapaport, Alison J, Larocque, Daniel, King, Gwendalyn D, Johnson, Stephen A, Liu, Chunyan, Xiong, Weidong, Candolfi, Marianela, Mondkar, Sonali, Ng, Philip, Palmer, Donna, Castro, Maria G, Lowenstein, Pedro R
Формат: Artigo
Язык:Inglês
Опубликовано: 2007
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268647/
https://ncbi.nlm.nih.gov/pubmed/17895861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.mt.6300305
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