One-year Expression From High-capacity Adenoviral Vectors in the Brains of Animals With Pre-existing Anti-adenoviral Immunity: Clinical Implications

The main challenge of gene therapy is to provide long-term, efficient transgene expression. Long-term transgene expression from first generation adenoviral vectors (Advs) delivered to the central nervous system (CNS) is elicited in animals not previously exposed to adenovirus (Ad). However, upon sys...

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Main Authors: Barcia, Carlos, Jimenez-Dalmaroni, Maximiliano, Kroeger, Kurt M, Puntel, Mariana, Rapaport, Alison J, Larocque, Daniel, King, Gwendalyn D, Johnson, Stephen A, Liu, Chunyan, Xiong, Weidong, Candolfi, Marianela, Mondkar, Sonali, Ng, Philip, Palmer, Donna, Castro, Maria G, Lowenstein, Pedro R
Format: Artigo
Sprog:Inglês
Udgivet: 2007
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268647/
https://ncbi.nlm.nih.gov/pubmed/17895861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.mt.6300305
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