One-year Expression From High-capacity Adenoviral Vectors in the Brains of Animals With Pre-existing Anti-adenoviral Immunity: Clinical Implications

The main challenge of gene therapy is to provide long-term, efficient transgene expression. Long-term transgene expression from first generation adenoviral vectors (Advs) delivered to the central nervous system (CNS) is elicited in animals not previously exposed to adenovirus (Ad). However, upon sys...

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Autors principals: Barcia, Carlos, Jimenez-Dalmaroni, Maximiliano, Kroeger, Kurt M, Puntel, Mariana, Rapaport, Alison J, Larocque, Daniel, King, Gwendalyn D, Johnson, Stephen A, Liu, Chunyan, Xiong, Weidong, Candolfi, Marianela, Mondkar, Sonali, Ng, Philip, Palmer, Donna, Castro, Maria G, Lowenstein, Pedro R
Format: Artigo
Idioma:Inglês
Publicat: 2007
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268647/
https://ncbi.nlm.nih.gov/pubmed/17895861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.mt.6300305
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