Effectiveness and Preclinical Safety Profile of Doxycycline to Be Used “Off-Label” to Induce Therapeutic Transgene Expression in a Phase I Clinical Trial for Glioma

Glioblastoma multiforme (GBM) is the most common malignant primary brain cancer in adults; it carries a dismal prognosis despite improvements in standard of care. We developed a combined gene therapy strategy using (1) herpes simplex type 1-thymidine kinase in conjunction with the cytotoxic prodrug...

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Detalhes bibliográficos
Main Authors: VanderVeen, Nathan, Paran, Christopher, Krasinkiewicz, Jonathan, Zhao, Lili, Palmer, Donna, Hervey-Jumper, Shawn, Ng, Philip, Lowenstein, Pedro R., Castro, Maria G.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2013
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4003468/
https://ncbi.nlm.nih.gov/pubmed/24007469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/humc.2013.139
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